Glycoprotein Macrophage Activating Factor
Glycoprotein Macrophage Activating Factor, GcMAF, is a protein produced by modification of vitamin D-binding protein.
Biochemically, GcMAF results from sequential deglycosylation of the vitamin D-binding protein, which is naturally promoted by lymphocytes (B and T cells).
The resulting protein may be a macrophage activating factor (MAF).
MAFs are lymphokines that control the expression of antigens on the surface of macrophages, and one of their functions is to make macrophages become cytotoxic to tumors.
Macrophages (meaning “big eaters” in Greek) are an important type of white blood cell.
They patrol the body, eating up foreign invaders and dead cells.
They also help to alert other immune cells to the presence of infections.
Macrophages can be stirred into action by a small sugar-coated protein (glycoprotein) called Gc-MAF.
Some of the beneficial findings are under debate and questioning.